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Targeting BCL-XL with a Novel VHL-Based BCL-XL Degrader DT-2216 in Pre-Clinical JAK2-Mutant AML Post-MPN Models
Authors: Zhe WANG | Qi Zhang | Anna Skwarska | Cassandra L. Ramage | Guangrong Zheng | Kira Gritsman | Kapil N. Bhalla | Naveen Pemmaraju | Daohong Zhou | Jeffrey W Tyner | Marina Y. Konopleva
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Synergistic Growth Inhibition of NPM1 Mutant AML PDX By Combined Therapy with BCL-2 Inhibitor Venetoclax (ABT-199) and Menin Inhibitor DS-1594b In Vivo
Authors: Valerio Ciaurro | Marina Y. Konopleva | Naval Daver | Anna Skwarska | Maria Paola Martelli
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A STAT3 Degrader Demonstrates Pre-Clinical Efficacy in Venetoclax Resistant Acute Myeloid Leukemia
Authors: Samarpana Chakraborty | Claudia Morganti | Joyoti Dey | Hui Zhang | Srinivas Aluri | Nadege Gitego | Kith Pradhan | Bianca Rivera | Yogesh Chutake | Anna Skwarska | Ioannis Mantzaris | Mendel Goldfinger | Eric J Feldman | Gaurav S Choudhary | Stefan Hubner | Yihua Qiu | Brandon D. Brown | Amit Verma | Evripidis Gavathiotis | Marina Y. Konopleva | Steven M. Kornblau | Jared Gollob | Keisuke Ito | Aditi Shastri
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The Prevalence and Mutational Spectrum of Clonal Hematopoiesis in Diverse Populations in New York City
Authors: Varun Gupta | Mariko Isshiki | Anna Skwarska | Kith Pradhan | Amit K. Verma | Marina Y. Konopleva | Aditi Shastri | Srilakshmi Raj
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Venetoclax Synergizes with IMGN632, a Novel CD123-Targeting Antibody Conjugated to a DNA Alkylating Payload, By Suppressing DNA Damage Response and Potentiating Apoptosis in Acute Myeloid Leukemia in Vitro Models
Authors: Anna Skwarska | Vinitha Mary Kuruvilla | Qi Zhang | Sovira Chaudhry | Naval Daver | Krystal Watkins | Callum Mortimer Sloss | Patrick A. Zweidler-McKay | Deepa Sampath | Marina Y. Konopleva
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TET2 truncating mutations predict a worse outcome in blastic plasmacytoid dendritic cell neoplasm
Authors: Hannah Beird | C. Cameron Yin | Joseph D. Khoury | Sherry Pierce | Hussein A. Abbas | Li Zhao | Anna Skwarska | Muzaffar Qazilbash | Marina Konopleva | P. Andrew Futreal | Naveen Pemmaraju
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Menin Inhibitor DS-1594b Drives Differentiation and Induces Synergistic Lethality in Combination with Venetoclax in AML Cells with MLL-Rearranged and NPM1 Mutation
Authors: Valerio Ciaurro | Anna Skwarska | Naval Daver | Marina Konopleva
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Lipophagy As a Mechanism of Resistance in T-ALL Following Energetic Crisis Induced By Oxphos/MCT1 Blockade: Strategies to Eradicate Residual Disease
Authors: Natalia Baran | Shraddha Patel | Cassandra L Ramage | Alessia Lodi | Jose Enriquez Ortiz | Yogesh Dhungana | Meghan Collins | Anna Skwarska | Connie Weng | Kala Hayes | Zhihong Zeng | Laurie Cooper | Richard Eric Davis | Gheath Alatrash | Joseph R Marszalek | Jiyang Yu | Pratip K Bhattacharya | Stefano Tiziani | Marina Konopleva
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Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and In Vivo
Authors: Anna Skwarska | Donia M Moujalled | Paul F Panis | Shraddha Patel | Qi Zhang | Shelley Herbrich | Vinitha Kurvilla | Natalia Baran | Giovanna Pomilio | Ensar Halilovic | Prakash Mistry | Vivian Ruvolo | Peter P. Ruvolo | Alix Derréal | Sebastien Banquet | Magdalena Niemira | Adam Kretowski | Naval Daver | Michael Andreeff | Andrew H. Wei | Marina Konopleva
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Accumulation of Intracellular L-Lactate and Irreversible Disruption of Mitochondrial Membrane Potential upon Dual Inhibition of Oxphos and Lactate Transporter MCT-1 Induce Synthetic Lethality in T-ALL Via Mitochondrial Exhaustion
Authors: Natalia Baran | Shraddha Patel | Alessia Lodi | Jose Enriquez Ortiz | Yogesh Dhungana | Meghan Collins | Anna Skwarska | Connie Weng | Cassandra L Ramage | Kala Hayes | Zhihong Zeng | Eric Davis | Gheath Alatrash | Joseph R Marszalek | Jiyang Yu | Pratip K Bhattacharya | Stefano Tiziani | Marina Konopleva
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Overcoming NOTCH1-Driven Chemoresistance in T-Cell Acute Lymphoblastic Leukemia Via Metabolic Intervention with Oxphos Inhibitor
Authors: Natalia Baran | Alessia Lodi | Yogesh Dhungana | Shannon RENEE Sweeney | Pandey Renu | Shelley Herbrich | Fieke W Hoff | Anna Skwarska | Mecit Kaplan | Vinitha Mary Kuruvilla | Antonio Cavazos | Marc Warmoes | Shanti Rojas-Sutterlin | Andre Haman | Diogo Troggian Veiga | Ken Furudate | Helen Ma | Karine Harutyunyan | Wentao Yang | Mihai Gagea | Di Du | May Daher | Luciana Melo Garcia | Sujan Piya | Vivian Ruvolo | Sriram Shanmugavelandy | Ningping Feng | Jason P Gay | Ondrej Havranek | Jared Henderson | Katarzyna Tomczak | Marcin Kaminski | Daniel Herranz | Adolfo Ferrando | Elias Jabbour | Maria E Di Francesco | David T. Teachey | Terzah M. Horton | Katayoun Rezvani | Jun J. Yang | Steven M. Kornblau | Eric Davis | Koichi Takahashi | Michael Andreeff | Joseph R Marszalek | Philip Lorenzi | Jiyang Yu | Stefano Tiziani | Trang Hoang | Marina Konopleva
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Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism
Authors: Natalia Baran | Alessia Lodi | Shannon Renee Sweeney | Vinitha Mary Kuruvilla | Antonio Cavazos | Daniel Herranz | Anna Skwarska | Marc Warmoes | Eric Davis | Karine Harutyunyan | Ningping Feng | Jason P Gay | Marcin Kaminski | Sergej Konoplev | Elias Jabbour | Adolfo A. Ferrando | Maria E Di Francesco | Philip Lorenzi | Joseph R Marszalek | Stefano Tiziani | Marina Y Konopleva | Pandey Renu
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Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition
Authors: Natalia Baran | Alessia Lodi | Shannon Renee Sweeney | Pandey Renu | Vinitha Mary Kuruvilla | Antonio Cavazos | Daniel Herranz | Anna Skwarska | Marc Warmoes | R. Eric Davis | Karine Harutyunyan | Ningping Feng | Jason P Gay | Sergej Naumovich Konoplev | Marcin Kaminski | Jeffrey J Kovacs | Di Du | Elias J. Jabbour | Adolfo A. Ferrando | Maria E Di Francesco | Philip L Lorenzi | Joseph R Marszalek | Stefano Tiziani | Marina Y. Konopleva
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Imidazoacridinone C-1311 Triggers a Switch from Autophagy to Apoptosis By Blocking FLT3-Dependent ATF4 Transcription Factor in FLT3-ITD Acute Myeloid Leukemia
Authors: Anna Skwarska | Natalia Baran | Marina Y. Konopleva
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